Peptides vs Small Molecules: What Actually Differs in the Lab
Peptides vs small molecules: size, synthesis, stability, analysis and how each reaches its target, and why a peptide catalogue also lists non-peptides.
Archive
Category: Education
Scrambled Peptide Controls: How to Design a Credible Peptide Experiment
What a scrambled peptide control tests, how to design one, when alanine scans or inactive analogues work better, and the pitfalls that undermine controls.
Amino Acid Analysis: How a Peptide’s Content and Composition Are Measured
Amino acid analysis explained: acid hydrolysis, derivatization and quantitation, which residues are lost, and how AAA compares with CHN, qNMR and UV.
LC-MS Explained: How a Peptide’s Identity Is Confirmed
What LC-MS is, how electrospray turns a peptide into multiply charged ions, what a mass match does and does not prove, and the three things on a certificate that LC-MS cannot answer.
Bioregulator Peptides Explained: The Khavinson Short Peptides
Bioregulator peptides explained: the Khavinson short peptides, the sequences behind names like Cortagen and Livagen, how they've been studied, and what the evidence doesn't show.
Research Peptide Glossary: 46 Terms Every Lab Should Know
Plain-English definitions of 46 research-peptide terms, from HPLC, mass spectrometry and COAs to counter-ions, net peptide content, molarity, RUO and DIN, grouped by topic.
Neurotrophic Factors: NGF, BDNF and the Neurogenesis Question
What NGF and BDNF are, why precursor forms do the opposite of mature ones, why adult human neurogenesis is still contested, and exactly what the published Semax, Selank and P021 work measured.
Cyclic AMP and Protein Kinase A Explained
How a peptide signal outside a cell becomes a response inside it: adenylyl cyclase, cyclic AMP, protein kinase A and CREB, why GHRH analogues and growth hormone secretagogues use different routes, and what the cascade diagram leaves out.
α-MSH and the Melanocortin System Explained
What alpha-MSH is, how one precursor protein yields it alongside ACTH and beta-endorphin, what each of the five melanocortin receptors actually responds to, and where KPV fits as its C-terminal fragment.
NF-κB Explained: The Switch Behind Inflammation Research
What NF-kB actually is, how IkB and the IKK complex throw the switch, why no direct NF-kB inhibitor has been approved, and what the published KPV, LL-37 and GHK-Cu work really measured.
