Description
Vesilute is the dipeptide Glu-Asp (ED), the two-residue core shared by Ovagen, Chonluten, Crystagen, Pinealon and many other St. Petersburg bioregulators. It is catalogued as bladder-associated, but we found no published study of the dipeptide in bladder or urinary-tract tissue. Pure Peptides Canada supplies it as a lyophilized research reagent in 20 mg vials, with an independent Janoshik HPLC and mass-spectrometry report, CAD pricing and tracked shipping from inside Canada.
Vesilute at a glance
- What it is: L-glutamyl-L-aspartic acid (ED), a synthetic dipeptide from Vladimir Khavinson’s bioregulator programme.
- What researchers study: the Glu-Asp pair as a baseline or control for the longer ED-family peptides; the dipeptide itself has almost no dedicated literature.
- Evidence level: minimal. The only paper we found that names Vesilute is a 2016 computer docking study from its developers, which predicted weak DNA binding. We found no cell, animal or human studies of the dipeptide.
- Supplied as: sealed lyophilized powder, 20 mg, single vial or box of 10.
- Delivery: ships from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
Vesilute
Glu-Asp · ED dipeptide · bladder-associated bioregulator
- E
- D
Glutamic acid, aspartic acid.
- Length
- 2 amino acids
- Molecular formula
- C9H14N2O7
- Molecular weight
- ≈ 262.2 g/mol
- Family
- Khavinson short-peptide bioregulators
- Form
- Lyophilized powder, sealed vial
- Sizes
- 20 mg (single or box of 10)
- SKU
- PP-VESILUTE
Where the evidence stands
- Cell studies
- Animal models
- Controlled human trials
- Approved medicine
Little primary research on Vesilute is publicly accessible; most of what circulates comes from the developers’ group. Vesilute is not an approved medicine.
What is Vesilute?
Vesilute is a synthetic dipeptide, L-glutamyl-L-aspartic acid. Both residues carry carboxylic-acid side chains, so at neutral pH it has a net charge of about −2, more negative than the other two dipeptides in our range, Vilon (Lys-Glu) and thymogen (Glu-Trp).
The Glu-Asp pair recurs throughout the St. Petersburg programme. In the developers’ 2016 modelling study of 19 short peptides, 15 contained it, including Ovagen (EDL), Chonluten (EDG), Crystagen (EDP), Pinealon (EDR) and Livagen (KEDA). Because peptides assigned to many different tissues share it, the bare dipeptide is a logical baseline or control for what each added residue contributes, and none of the accessible papers explains how it alone would carry a bladder-specific signal.
What published studies report
- Computer docking. The only paper we found that names Vesilute is a modelling study of 19 short peptides by Khavinson, Lin’kova and Tarnovskaya (Bulletin of Experimental Biology and Medicine, 2016). It predicted that the ED dipeptide binds the DNA sequence ATTT only weakly, and the authors attribute the weak binding of dipeptides to their small contact area. The work is computational, with no binding experiments.
- Not tested on its own. The developers’ 2021 systematic review of peptide regulation of gene expression (Khavinson and colleagues, Molecules) discusses Glu-Asp only as part of longer peptides and reports no experiments on the dipeptide alone.
- Relatives tested, the dipeptide not. A 2023 explant study tested three ED-family tripeptides, Glu-Asp-Arg, Glu-Asp-Pro and Glu-Asp-Leu, and reported increased cell proliferation in rat cortex, liver and spleen tissue; Glu-Asp itself was not among the peptides tested (Chalisova and colleagues, Integrative Physiology, 2023).
What is not established
Any biological effect of the dipeptide, any link to bladder or urinary-tract tissue, and whether it binds DNA in cells as modelled. Vesilute is suited to structure–activity designs in which the bare Glu-Asp pair is the comparison, not to studies that depend on a known effect.
Regulatory status: Vesilute is not an authorized drug in Canada. We sell it strictly as a laboratory reagent for in-vitro research.
Why researchers order Vesilute from Pure Peptides Canada
Add a 20 mg vial or a box of 10 above. Orders over $299 ship free across Canada.
See lab resultsVesilute FAQ
Where can I buy Vesilute in Canada?
Pure Peptides Canada stocks Vesilute as a lyophilized research reagent in 20 mg vials and ships it from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
Is Vesilute the same as Vesugen?
No. Vesilute is the dipeptide Glu-Asp (about 262.2 g/mol), associated by its developers with the bladder. Vesugen is the tripeptide Lys-Glu-Asp (about 390.4 g/mol), associated with blood vessels.
How is Vesilute related to Ovagen, Chonluten, Crystagen and Pinealon?
Vesilute is their shared core. Each of those tripeptides is Glu-Asp followed by one more residue: leucine in Ovagen, glycine in Chonluten, proline in Crystagen and arginine in Pinealon. Comparing them with Vesilute isolates what that third residue contributes.
How much research is there on Vesilute?
Very little. The only paper we found that names it is a 2016 computer docking study from its developers, which predicted weak DNA binding. We found no cell, animal or human study of the Glu-Asp dipeptide, so it suits comparative work on the ED family rather than studies that depend on an established literature.
Can Vesilute be used in people or animals?
No. This product is for in-vitro laboratory research only and is not a drug, supplement or food. We do not provide dosing or administration information.
References
- Khavinson VKh, Lin’kova NS, Tarnovskaya SI. Short peptides regulate gene expression. Bull Exp Biol Med. 2016;162(2):288–292. doi:10.1007/s10517-016-3596-7
- Khavinson VK, Popovich IG, Linkova NS, et al. Peptide regulation of gene expression: a systematic review. Molecules. 2021;26(22):7053. doi:10.3390/molecules26227053
- Chalisova NI, Ivanova PN, Egozova ES, Nikitina EA. The stimulating effect of short peptides on cellular proliferation in organotypic tissue culture [in Russian]. Integrative Physiology. 2023;4(2):225–234. doi:10.33910/2687-1270-2023-4-2-225-234
For laboratory research use only. Not a drug, supplement, food or cosmetic, not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Evelyn R. –
Highly recommend to anyone with urinary issues. Really helped me manage my symptoms