Description
N-Acetyl Epithalon is the tetrapeptide Ala-Glu-Asp-Gly (Epitalon) with an acetyl cap on its N-terminus, a modification intended to slow enzymatic breakdown of an otherwise very short-lived peptide. It is stocked for stability and analogue-comparison work in telomere and ageing-biology research. Pure Peptides Canada supplies it as a lyophilized research reagent in 20 mg vials, with CAD pricing and tracked shipping from inside Canada.
N-Acetyl Epithalon at a glance
- What it is: Ac-Ala-Glu-Asp-Gly, the St. Petersburg tetrapeptide Epitalon with an acetylated N-terminus.
- Why the acetyl group: a four-residue peptide is quickly trimmed by aminopeptidases. Capping the N-terminus blocks that route.
- Evidence level: published research, mostly from one group, is on standard Epitalon. Data on the acetylated form is limited.
- Supplied as: sealed lyophilized powder, 20 mg, single vial or box of 10.
- Delivery: ships from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
N-Acetyl Epithalon
NA-Epithalon · Ac-Epitalon · Ac-AEDG
- Ac
- A
- E
- D
- G
Blue: N-terminal acetyl cap. The four residues are identical to standard Epithalon.
- Length
- 4 amino acids, acetylated N-terminus
- Molecular formula
- C16H24N4O10
- Molecular weight
- ≈ 432 g/mol (Epithalon 390.35 + acetyl)
- Parent peptide
- Epithalon, AEDG
- Form
- Lyophilized powder, sealed vial
- Sizes
- 20 mg (single or box of 10)
- SKU
- PP-NAEPITHALON
Where the evidence stands
- Cell studies
- Animal models
- Controlled human trials
- Approved medicine
Most published research is on standard Epithalon. Data specific to the acetylated form is limited.
What is N-Acetyl Epithalon?
Epithalon was designed by Vladimir Khavinson’s group in St. Petersburg as a defined synthetic version of a pineal-gland extract, and it is best known for a 2003 report of telomerase activation in cultured human cells. At only four amino acids, it offers enzymes very little to work around, so it breaks down quickly in biological samples.
N-acetylation is a standard way to slow that down. Aminopeptidases need a free amino group at the N-terminus, and an acetyl cap removes it. N-Acetyl Epithalon keeps the AEDG sequence while changing that one chemical handle, which makes it useful for asking whether stability, rather than sequence alone, shapes results in cell models. Run it alongside standard Epithalon for the cleanest comparison.
Testing note: lab reports are listed on our Lab Testing page. Check that the report names the acetylated form. Its mass should be about 42 Da higher than standard Epithalon. Regulatory status: N-Acetyl Epithalon is not an authorized drug in Canada, and Health Canada’s April 2026 public advisory on unauthorized injectable peptides names its parent compound, Epitalon. We sell it strictly as a laboratory reagent for in-vitro research.
What N-Acetyl Epithalon research looks at
- Peptide stability: degradation of acetylated versus standard AEDG in biological matrices.
- Telomere biology: telomerase activity in somatic cell cultures, compared with the parent peptide.
- Short-peptide gene regulation: proposed interactions between bioregulator peptides and chromatin.
- Bioregulator comparisons: alongside Pinealon, Vilon and related short peptides.
Why researchers order N-Acetyl Epithalon from Pure Peptides Canada
Add a 20 mg vial or a box of 10 above. Orders over $299 ship free across Canada.
See lab resultsN-Acetyl Epithalon FAQ
Where can I buy N-Acetyl Epithalon in Canada?
Pure Peptides Canada stocks N-Acetyl Epithalon as a lyophilized research reagent in 20 mg vials and ships it from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
What is the difference between N-Acetyl Epithalon and Epithalon?
The sequence is identical (Ala-Glu-Asp-Gly). N-Acetyl Epithalon adds an acetyl group to the N-terminus, which blocks aminopeptidase breakdown and is intended to improve stability. Most published research is on standard Epithalon.
How do I confirm I have the acetylated form?
By mass. The acetyl group adds about 42 Da, so the identity mass should be near 432 Da rather than Epithalon’s 390.35 Da. Our COA guide explains how to read a report.
Is N-Acetyl Epithalon approved in Canada?
No. It is not an authorized drug in Canada or elsewhere. It is sold here only as a laboratory reagent for in-vitro research.
Can N-Acetyl Epithalon be used in people or animals?
No. This product is for in-vitro laboratory research only and is not a drug, supplement or food. We do not provide dosing or administration information.
For laboratory research use only. Not a drug, supplement, food or cosmetic, not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Reviews
There are no reviews yet.