Description
Humanin is a 24-amino-acid peptide discovered in 2001 while screening for genes that protect neurons in Alzheimer’s disease. It was the first of the mitochondrial-derived peptides, the family that later grew to include MOTS-c. Pure Peptides Canada supplies it as a lyophilized research reagent in 10 mg vials, with an independent Janoshik HPLC and mass-spectrometry report, CAD pricing and tracked shipping from inside Canada.
Humanin at a glance
- What it is: MAPRGFSCLLLLTSEIDLPVKRRA, a short peptide encoded within the mitochondrial 16S rRNA gene.
- What researchers study: neuron survival against amyloid-beta toxicity, apoptosis signalling through Bax and IGFBP-3, insulin sensitivity and cellular stress responses.
- Evidence level: extensive cell and animal work. Human data is limited to observational studies of circulating levels.
- Supplied as: sealed lyophilized powder, 10 mg, single vial or box of 10.
- Delivery: ships from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
Humanin
HN · mitochondrial-derived peptide · MT-RNR2-encoded
- M
- A
- P
- R
- G
- F
- S
- C
- L
- L
- L
- L
- T
- S
- E
- I
- D
- L
- P
- V
- K
- R
- R
- A
One-letter code, N-terminus to C-terminus.
- Length
- 24 amino acids
- Molecular formula
- C119H204N34O32S2
- Molecular weight
- ≈ 2687 g/mol
- Encoded by
- Mitochondrial 16S rRNA gene (MT-RNR2)
- Form
- Lyophilized powder, sealed vial
- Sizes
- 10 mg (single or box of 10)
- SKU
- PP-HUMANIN
Where the evidence stands
- Cell studies
- Animal models
- Controlled human trials
- Approved medicine
Humanin research is preclinical. Human studies so far measure natural circulating levels; none test it as a treatment.
What is humanin?
In 2001, Ikuo Nishimoto’s group in Tokyo screened genes from the relatively spared occipital cortex of an Alzheimer’s patient, looking for anything that protected neurons from disease-related damage. They found a short sequence that blocked cell death triggered by Alzheimer’s-linked mutations and amyloid-beta, and named its peptide product humanin. The sequence turned out to sit inside the mitochondrial 16S rRNA gene, making humanin the founding member of the mitochondrial-derived peptide family.
Since then, humanin has been shown in cell and animal studies to act both inside cells, binding the pro-death protein Bax and IGFBP-3, and outside them through receptors including FPRL1 and a gp130-containing complex. Circulating levels fall with age in people and rodents. Its more potent analogue, HNG (S14G-humanin), is widely used in mouse studies. As with MOTS-c, the findings are preclinical.
What humanin research looks at
- Neuroprotection: neuron survival against amyloid-beta and Alzheimer’s-linked mutations.
- Apoptosis signalling: interactions with Bax, tBid and IGFBP-3.
- Metabolism: insulin sensitivity and glucose handling in rodent models.
- Cardiovascular models: endothelial function and ischaemia-reperfusion injury.
- Mitochondrial peptide family: comparisons with MOTS-c and the synthetic SS-31.
Regulatory status: humanin is not an authorized drug in Canada. We sell it strictly as a laboratory reagent for in-vitro research.
Why researchers order humanin from Pure Peptides Canada
Add a 10 mg vial or a box of 10 above. Orders over $299 ship free across Canada.
See lab resultsHumanin FAQ
Where can I buy humanin in Canada?
Pure Peptides Canada stocks humanin as a lyophilized research reagent in 10 mg vials and ships it from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
What is the difference between humanin and MOTS-c?
Both are mitochondrial-derived peptides. Humanin (24 residues) is encoded in the 16S rRNA gene and is studied mainly for cell survival and neuroprotection. MOTS-c (16 residues) is encoded in the 12S rRNA gene and is studied mainly for metabolism and AMPK signalling.
What is HNG?
HNG, or S14G-humanin, is a synthetic analogue with glycine in place of serine at position 14. It is reported to be considerably more potent than native humanin in cell studies. This listing is native humanin.
Is this humanin third-party tested?
Yes. A certificate of analysis is available on request through our Lab Testing page. Our COA guide explains how to read it.
Can humanin be used in people or animals?
No. This product is for in-vitro laboratory research only and is not a drug, supplement or food. We do not provide dosing or administration information.
For laboratory research use only. Not a drug, supplement, food or cosmetic, not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Reviews
There are no reviews yet.