Description
NAD+ (nicotinamide adenine dinucleotide) is the central redox coenzyme of cellular metabolism and the substrate for sirtuins, PARPs and CD38. It is one of the most widely used reagents in biochemistry and ageing research. Pure Peptides Canada supplies it as a lyophilized research reagent in generous 500 mg vials, with an independent Janoshik HPLC and mass-spectrometry report, CAD pricing and tracked shipping from inside Canada.
NAD+ at a glance
- What it is: the oxidized form of the NAD+/NADH redox pair, a dinucleotide made of nicotinamide and adenine nucleotides. It is a coenzyme, not a peptide.
- Where it is used: dehydrogenase-coupled assays, enzyme kinetics, sirtuin and PARP studies, mitochondrial and metabolic research, and NAD+/NADH ratio work.
- Why it matters in ageing research: tissue NAD+ levels decline with age in animal studies, which made NAD+ metabolism a major research field.
- Supplied as: sealed lyophilized powder, 500 mg, single vial or box of 10.
- Delivery: ships from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
NAD+
Nicotinamide adenine dinucleotide (oxidized) · β-NAD · coenzyme I
- Compound class
- Pyridine dinucleotide coenzyme
- Molecular formula
- C21H27N7O14P2
- Molecular weight
- ≈ 663.4 g/mol
- CAS number
- 53-84-9
- Key enzymes
- Dehydrogenases, sirtuins (SIRT1–7), PARPs, CD38
- Form
- Lyophilized powder, sealed vial
- Sizes
- 500 mg (single or box of 10)
- SKU
- PP-NADPLUS
Where the evidence stands
- Cell studies
- Animal models
- Human studies
- Approved medicine
NAD+ biology is well established. Human studies mostly involve oral precursors such as NR and NMN, not NAD+ itself.
What is NAD+?
NAD+ was identified by Arthur Harden and William Young in 1906 as a “cozymase” needed for yeast fermentation, and its structure and redox role were worked out over the following decades. It shuttles electrons in glycolysis, the TCA cycle and oxidative phosphorylation, flipping between its oxidized form (NAD+) and reduced form (NADH). That makes it an indispensable cofactor in any assay built on dehydrogenase activity.
Since the 2000s, NAD+ has also become a focus of ageing biology. Sirtuins and PARPs consume NAD+ as a substrate, and animal studies report that NAD+ levels fall in many tissues with age, partly through rising CD38 activity. Much of the human research has used precursors such as nicotinamide riboside and NMN rather than NAD+ itself. For in-vitro work, NAD+ remains the direct reagent for controlling cofactor supply.
What NAD+ research looks at
- Enzyme kinetics: dehydrogenase-coupled assays and standard curves at defined cofactor concentrations.
- Sirtuin and PARP biology: NAD+-dependent deacylation and ADP-ribosylation in cell-free and lysate systems.
- CD38 and NAD+ decline: NAD+ consumption in ageing and inflammation models.
- Mitochondrial metabolism: NAD+/NADH ratios and oxidative phosphorylation.
- Related pathways: NNMT inhibition with 5-Amino-1MQ and mitochondrial peptides such as MOTS-c.
Handling note: NAD+ in solution is sensitive to pH and heat. Prepare working solutions close to use and aliquot stock to limit freeze-thaw cycles. Regulatory status: Health Canada’s April 2026 public advisory on unauthorized injectable peptides lists NAD+ among the products of concern. We supply it as a laboratory reagent only, not as a drug, supplement or infusion product.
Why researchers order NAD+ from Pure Peptides Canada
Add a 500 mg vial or a box of 10 above. Orders over $299 ship free across Canada.
See lab resultsNAD+ FAQ
Where can I buy NAD+ in Canada?
Pure Peptides Canada stocks NAD+ as a lyophilized research reagent in 500 mg vials and ships it from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
Is NAD+ a peptide?
No. NAD+ is a dinucleotide coenzyme built from two nucleotides. We stock it alongside peptides because it is central to the same metabolic and ageing research programmes.
What is the difference between NAD+ and NADH?
They are the oxidized and reduced forms of the same molecule. NAD+ accepts electrons in metabolic reactions and becomes NADH. This product is the oxidized NAD+ form.
Is this NAD+ third-party tested?
Yes. An HPLC purity and mass-spectrometry identity report from Janoshik Analytical, an independent lab, is listed on our Lab Testing page. Our COA guide explains how to read it.
Can this NAD+ be used in people or animals?
No. This product is for in-vitro laboratory research only. It is not a drug, supplement or infusion product, and we do not provide dosing or administration information.
For laboratory research use only. Not a drug, supplement, food or cosmetic, not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
In depth: NAD+, NMN and nicotinamide riboside: what the research shows covers how cells make and use NAD+, what the human trials of its precursors found, and how it is measured.
James Thompson –
Exactly what I was looking for. Fast shipping to Surrey.
William Blackfoot –
Ex drug addict and alcoholic here (now recovered) and a friend recommended NAD+ to help with severe withdrawal symptoms and boy was i happy to have this in my system.. not only that but this stuff really cleared out my brain fog and gave me mental clarity that ive not had before..these peptides are f**king cool man. experimental and all, i dont see how it couldve been worse than what ive put in my body on a regular basis most of my life.. and most people worried about taking these things, should probably look at what they put in their body on a daily basis. tons of sugar, bad food, smoking, alcohol, drugs.. and youre worried about peptides eh? hahahaha.. OK . checkin off here later