Description
TB-500 Fragment is the seven-residue peptide Ac-LKKTETQ, the actin-binding core of thymosin beta-4 and the part of the molecule linked to its cell-migration activity. Pure Peptides Canada supplies it as a lyophilized research reagent in 10 mg vials, with an independent Janoshik HPLC and mass-spectrometry report, CAD pricing and tracked shipping from inside Canada.
TB-500 Fragment at a glance
- What it is: N-acetylated Leu-Lys-Lys-Thr-Glu-Thr-Gln, residues 17 to 23 of thymosin beta-4, where the parent protein binds G-actin.
- Why it is studied: to test how much of thymosin beta-4’s migration and angiogenesis activity sits in this short motif, using a molecule about one-sixth the size.
- Evidence level: cell and animal studies. No controlled human trials.
- Supplied as: sealed lyophilized powder, 10 mg, single vial or box of 10.
- Delivery: ships from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
TB-500 Fragment
Ac-LKKTETQ · thymosin β4 (17-23) · actin-binding motif
- Ac
- L
- K
- K
- T
- E
- T
- Q
Blue: N-terminal acetyl cap. Residues match positions 17 to 23 of full-length thymosin beta-4.
- Length
- 7 amino acids, acetylated N-terminus
- Molecular formula
- C38H68N10O14
- Molecular weight
- ≈ 889 g/mol
- Parent protein
- Thymosin beta-4 (43 residues, ≈ 4963 g/mol)
- Form
- Lyophilized powder, sealed vial
- Sizes
- 10 mg (single or box of 10)
- SKU
- PP-TB500FRAG
Where the evidence stands
- Cell studies
- Animal models
- Controlled human trials
- Approved medicine
Fragment research is preclinical. It is not an approved medicine anywhere.
What is the TB-500 Fragment?
Thymosin beta-4 controls cell movement by holding monomeric actin in reserve, and structural work traced that job to a short central stretch, LKKTETQ. In the early 2000s, studies tested whether that motif alone could reproduce some of the parent protein’s effects, and reported that it promoted endothelial cell migration and blood-vessel formation in cell and animal models. That made the acetylated seven-residue peptide a practical research tool: far cheaper to make and characterize than the full 43-residue protein.
The fragment is also part of the reason the name TB-500 causes confusion. Some sellers use TB-500 for this short peptide, others for full thymosin beta-4. We list them separately. Because the full protein weighs about 4963 Da and the fragment about 889 Da, the identity mass on the lab report shows immediately which molecule is in the vial.
What TB-500 Fragment research looks at
- Actin binding: how the LKKTETQ motif interacts with G-actin compared with the full protein.
- Cell migration: endothelial-cell and keratinocyte movement in vitro.
- Angiogenesis: vessel formation in cell assays and animal models.
- Structure-activity work: which parts of thymosin beta-4 carry which activities.
- Analytical detection: the fragment is used as a reference standard in anti-doping test development.
Regulatory status: the TB-500 Fragment is not an authorized drug in Canada, and thymosin beta-4 and its derivatives are on the World Anti-Doping Agency prohibited list. We sell it strictly as a laboratory reagent for in-vitro research.
Why researchers order the TB-500 Fragment from Pure Peptides Canada
Add a 10 mg vial or a box of 10 above. Orders over $299 ship free across Canada.
See lab resultsTB-500 Fragment FAQ
Where can I buy TB-500 Fragment in Canada?
Pure Peptides Canada stocks the TB-500 Fragment (Ac-LKKTETQ) as a lyophilized research reagent in 10 mg vials and ships it from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
What is the difference between TB-500 and the TB-500 Fragment?
Full TB-500 is synthetic thymosin beta-4, a 43-residue protein of about 4963 Da. The fragment is only its seven-residue actin-binding motif, about 889 Da. They are different molecules for different study designs.
Why choose the fragment over full thymosin beta-4?
Researchers use the fragment to isolate the activity of the actin-binding motif, or when they want a smaller, simpler molecule for structure-activity or analytical work.
Is this TB-500 Fragment third-party tested?
Yes. Janoshik Analytical, an independent lab, tests by HPLC for purity and mass spectrometry for identity. Our COA guide explains how to read a report.
Is the TB-500 Fragment approved in Canada?
No. It is not an authorized drug in Canada or elsewhere. It is sold here only as a laboratory reagent for in-vitro research.
Can the TB-500 Fragment be used in people or animals?
No. It is for in-vitro laboratory research only and is not a drug, supplement or food. We do not provide dosing or administration information.
For laboratory research use only. Not a drug, supplement, food or cosmetic, not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
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