Description
Adipotide (FTPP, fat-targeted proapoptotic peptide) is an experimental two-part peptide from MD Anderson Cancer Center: a loop that homes to prohibitin on the blood vessels of white fat, joined to a D-amino-acid sequence that kills the cells it reaches. Pure Peptides Canada supplies it only as a lyophilized laboratory reagent in 10 mg vials. It is not a weight-loss product, not an approved medicine and not for human use.
Adipotide at a glance
- What it is: the prohibitin-binding loop CKGGRAKDC, a Gly-Gly linker, and the pro-apoptotic domain D(KLAKLAK)₂.
- What researchers study: vascular “zip codes” and homing peptides, prohibitin biology in adipose vasculature, and how targeted pro-apoptotic peptides act on endothelial cells.
- Evidence level: mouse and non-human primate studies. Kidney effects were the main finding of concern in monkeys. Not approved anywhere.
- Supplied as: sealed lyophilized powder, 10 mg, single vial or box of 10.
- Delivery: ships from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
Regulatory status: adipotide is an experimental compound and has not been approved anywhere. It is not a weight-loss product. We sell it strictly as a laboratory reagent for in-vitro research to qualified research buyers, and we do not provide dosing, administration or medical information.
Adipotide
FTPP · prohibitin-targeted pro-apoptotic peptide
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Dashed: the two cysteines that close the prohibitin-binding loop CKGGRAKDC. Blue (lower case): the D-amino-acid pro-apoptotic domain (KLAKLAK)₂, built from D-isomers so proteases cannot easily break it down.
- Length
- 25 residues: 9-residue homing loop, Gly-Gly linker, 14-residue D-amino-acid domain
- Target studied
- Prohibitin on the vasculature of white adipose tissue
- Origin
- Kolonin, Pasqualini and Arap, MD Anderson Cancer Center
- Form
- Lyophilized powder, sealed vial
- Sizes
- 10 mg (single or box of 10)
- SKU
- PP-ADIPOTIDE
Where the evidence stands
- Cell studies
- Animal models
- Controlled human trials
- Approved medicine
Published efficacy data come from mice and rhesus monkeys, with kidney effects reported in the monkeys. Adipotide is not an approved medicine.
What is adipotide?
Blood vessels in different tissues carry different surface markers, sometimes called vascular zip codes. Using in-vivo phage display, Mikhail Kolonin, Renata Pasqualini and Wadih Arap identified the cyclic peptide CKGGRAKDC, which homes to the blood vessels of white fat by binding prohibitin. In a 2004 Nature Medicine paper they fused it to D(KLAKLAK)₂, a peptide that disrupts mitochondrial membranes once inside a cell, so that the construct destroys the vessels that supply fat tissue.
The team reported weight loss in obese mice, and in a 2011 Science Translational Medicine study in spontaneously obese rhesus monkeys, reported weight loss and improved insulin sensitivity. The main adverse finding in the monkeys was kidney toxicity, which the investigators described as dose-dependent and reversible. A first-in-human study in obese men with prostate cancer was planned after the monkey work; adipotide has not been approved anywhere.
What adipotide research looks at
- Vascular targeting: homing peptides and tissue-specific endothelial markers.
- Prohibitin biology: prohibitin’s role at the surface of adipose endothelium.
- Pro-apoptotic peptides: how D(KLAKLAK)₂ damages mitochondrial membranes after cell entry.
- Renal effects: the kidney findings that limit this class of compound.
Ordering adipotide for laboratory research
Ask us for the expected mass for your lot, then check the report matches it.
See lab resultsAdipotide FAQ
Where can I buy adipotide in Canada?
Pure Peptides Canada supplies adipotide only as a lyophilized laboratory reagent in 10 mg vials, shipped from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299. It is not sold for human use.
Is adipotide approved?
No. Adipotide is an experimental compound that has been studied in mice and monkeys and has not been approved anywhere. It is not a weight-loss product.
How does adipotide work in research models?
Its CKGGRAKDC loop binds prohibitin on blood vessels in white fat, and its D(KLAKLAK)₂ domain damages the mitochondria of the cells it enters. In animal models, this destroyed the vessels supplying fat tissue.
What safety findings were reported?
In the 2011 rhesus monkey study, the main adverse finding was kidney toxicity, which the investigators described as dose-dependent and reversible.
Can adipotide be used in people or animals?
No. This product is for in-vitro laboratory research only and is not a drug, supplement or food. We do not provide dosing or administration information.
For laboratory research use only. Not a drug, supplement, food or cosmetic, not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
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