Description
PE-22-28 is a seven-residue peptide derived from spadin, a natural peptide that blocks the TREK-1 potassium channel in neurons. It was designed in France as a shorter, more stable version for depression-model research. Pure Peptides Canada supplies it as a lyophilized research reagent in 10 mg vials, with an independent Janoshik HPLC and mass-spectrometry report, CAD pricing and tracked shipping from inside Canada.
PE-22-28 at a glance
- What it is: a 7-residue fragment matching positions 22 to 28 of the sortilin propeptide (PE), the C-terminal end of the 17-residue peptide spadin.
- What researchers study: TREK-1 channel inhibition, fast-onset antidepressant-like behaviour in mice, neurogenesis and synaptic markers.
- Evidence level: cell and mouse studies, notably a 2017 comparison of shortened spadin analogues. No human trials.
- Supplied as: sealed lyophilized powder, 10 mg, single vial or box of 10.
- Delivery: ships from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
PE-22-28
Shortened spadin analogue · sortilin propeptide (22-28) · TREK-1 inhibitor peptide
- Length
- 7 amino acids
- Parent peptide
- Spadin, PE(12-28), 17 amino acids
- Origin
- Propeptide released during maturation of sortilin (NTSR3)
- Target
- TREK-1 (K2P2.1) two-pore-domain potassium channel
- Form
- Lyophilized powder, sealed vial
- Sizes
- 10 mg (single or box of 10)
- SKU
- PP-PE2228
Where the evidence stands
- Cell studies
- Animal models
- Controlled human trials
- Approved medicine
Research is preclinical, mainly in mice. PE-22-28 has not been tested in people.
What is PE-22-28?
TREK-1 is a potassium channel that helps set how excitable neurons are. Mice lacking it turned out to be resistant to depression-like behaviour, which made blocking it an attractive research target. In 2010 Jean Mazella’s group in Nice, France, reported that a 17-residue peptide released from sortilin, which they called spadin, blocks TREK-1 and produced antidepressant-like effects in mice within days rather than the weeks typical of conventional antidepressants.
Spadin is broken down quickly, so the same group tested shorter versions. In a 2017 study, PE-22-28, the last seven residues of spadin, kept or improved TREK-1 inhibition, lasted longer in mice and showed antidepressant-like activity along with markers of new neuron growth. It is now a reference compound for studying TREK-1 and fast-acting antidepressant mechanisms. All of the evidence is from cells and mice.
What PE-22-28 research looks at
- Ion-channel pharmacology: TREK-1 current inhibition in electrophysiology studies.
- Behavioural models: forced-swim and stress paradigms in mice.
- Neurogenesis: hippocampal cell proliferation and synaptic protein markers.
- Peptide optimization: how shortening spadin changes stability and activity.
Regulatory status: PE-22-28 is not an authorized drug in Canada. We sell it strictly as a laboratory reagent for in-vitro research.
Why researchers order PE-22-28 from Pure Peptides Canada
Add a 10 mg vial or a box of 10 above. Orders over $299 ship free across Canada.
See lab resultsPE-22-28 FAQ
Where can I buy PE-22-28 in Canada?
Pure Peptides Canada stocks PE-22-28 as a lyophilized research reagent in 10 mg vials and ships it from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
What is the difference between PE-22-28 and spadin?
Spadin is the 17-residue natural peptide. PE-22-28 is its last seven residues. In the 2017 mouse study it showed similar or better TREK-1 inhibition with greater stability.
What is TREK-1?
A two-pore-domain potassium channel that regulates neuronal excitability. Mice without TREK-1 show resistance to depression-like behaviour, which is why blocking it is studied as an antidepressant mechanism.
Is this PE-22-28 third-party tested?
Yes. An HPLC purity and mass-spectrometry identity report from Janoshik Analytical, an independent lab, is listed on our Lab Testing page. Our COA guide explains how to read it.
Can PE-22-28 be used in people or animals?
No. This product is for in-vitro laboratory research only and is not a drug, supplement or food. We do not provide dosing or administration information.
For laboratory research use only. Not a drug, supplement, food or cosmetic, not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
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