Description
P21 (P021) is a small peptidomimetic built from the active region of ciliary neurotrophic factor (CNTF), with an adamantane group added for stability. It was developed at the New York State Institute for Basic Research for neurogenesis and Alzheimer’s-model research. Pure Peptides Canada supplies it as a lyophilized research reagent in 10 mg vials, with an independent Janoshik HPLC and mass-spectrometry report, CAD pricing and tracked shipping from inside Canada.
P21 at a glance
- What it is: a short CNTF-derived peptide, capped and modified with an adamantylated glycine to resist breakdown and increase lipophilicity.
- What researchers study: neurogenesis in the hippocampus, BDNF expression, synaptic markers and tau pathology in Alzheimer’s-model mice.
- Evidence level: cell and mouse studies, largely from the group that designed it. No human trials.
- Supplied as: sealed lyophilized powder, 10 mg, single vial or box of 10.
- Delivery: ships from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
P21
P021 · CNTF-derived peptidomimetic · adamantylated peptide
- Origin
- Active region of ciliary neurotrophic factor (CNTF)
- Key modification
- C-terminal adamantylated glycine for stability and lipophilicity
- Developer
- Khalid Iqbal’s group, NYS Institute for Basic Research in Developmental Disabilities
- Identity
- Confirmed by mass on the lab report
- Form
- Lyophilized powder, sealed vial
- Sizes
- 10 mg (single or box of 10)
- SKU
- PP-P21
Where the evidence stands
- Cell studies
- Animal models
- Controlled human trials
- Approved medicine
Research is preclinical, mainly in transgenic mouse models. P21 has not been tested in people.
What is P21?
Ciliary neurotrophic factor supports neuron survival and the birth of new neurons, but as a full-sized protein it is a poor research tool for brain studies: it is large, short-lived and causes side effects in animals. Khalid Iqbal’s group in Staten Island, New York, screened fragments of CNTF to find the smallest region that kept its neurogenic activity, then modified it. They capped the ends and added an adamantane-bearing glycine, a bulky fat-soluble group, to improve stability and help the peptide reach brain tissue.
In mouse studies, including the triple-transgenic Alzheimer’s model, P021 was reported to increase hippocampal neurogenesis and BDNF expression, reduce tau abnormalities and improve performance in memory tasks. These are promising preclinical results from a small number of groups, and P21 has not entered human trials.
What P21 research looks at
- Neurogenesis: proliferation and survival of new neurons in the dentate gyrus.
- Neurotrophic signalling: BDNF expression and downstream pathways.
- Tau and amyloid models: pathology and cognition in transgenic Alzheimer’s mice.
- Synaptic plasticity: synaptic protein markers and dendritic structure.
- Peptidomimetic design: how an adamantane group changes stability and tissue distribution.
Regulatory status: P21 is not an authorized drug in Canada. We sell it strictly as a laboratory reagent for in-vitro research.
Why researchers order P21 from Pure Peptides Canada
Add a 10 mg vial or a box of 10 above. Orders over $299 ship free across Canada.
See lab resultsP21 FAQ
Where can I buy P21 in Canada?
Pure Peptides Canada stocks P21 (P021) as a lyophilized research reagent in 10 mg vials and ships it from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
Is P21 the same as P021?
Yes. P021 is the name used in the original research papers, and P21 is the common shorthand.
How is P21 related to CNTF?
It is built from the most active region of ciliary neurotrophic factor, a protein that supports neuron survival and neurogenesis, and is modified to be smaller and more stable than CNTF itself.
Is this P21 third-party tested?
Yes. An HPLC purity and mass-spectrometry identity report from Janoshik Analytical, an independent lab, is listed on our Lab Testing page. Our COA guide explains how to read it.
Can P21 be used in people or animals?
No. This product is for in-vitro laboratory research only and is not a drug, supplement or food. We do not provide dosing or administration information.
For laboratory research use only. Not a drug, supplement, food or cosmetic, not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
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