Description
DSIP, delta sleep-inducing peptide, is a nine-residue neuropeptide discovered in 1977, and it is still one of neuroscience’s open puzzles: widely studied, frequently cited and never fully explained. Pure Peptides Canada supplies it as a lyophilized research reagent in 5 and 10 mg vials, with an independent Janoshik HPLC and mass-spectrometry report, CAD pricing and tracked shipping from inside Canada.
DSIP at a glance
- What it is: the nonapeptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, first isolated in Basel from the blood of rabbits in induced sleep.
- What researchers study: sleep architecture, stress-hormone and LH regulation, and how a peptide with no identified receptor produces its effects.
- Evidence level: cell and animal studies plus small human sleep studies from the 1980s with mixed results.
- Supplied as: sealed lyophilized powder in 5 or 10 mg, single vial or box of 10.
- Delivery: ships from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
DSIP
Delta sleep-inducing peptide · emideltide · nonapeptide
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One-letter code, N-terminus to C-terminus: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu.
- Length
- 9 amino acids
- Molecular formula
- C35H48N10O15
- Molecular weight
- 848.8 g/mol
- CAS number
- 62568-57-4
- Form
- Lyophilized powder, sealed vial
- Sizes
- 5 mg · 10 mg (single or box of 10)
- SKU
- PP-DSIP
Where the evidence stands
- Cell studies
- Animal models
- Small human studies
- Approved medicine
Human sleep studies were small and inconsistent. DSIP is not an approved medicine anywhere.
What is DSIP?
In 1977 Guido Schoenenberger and Marcel Monnier in Basel reported a factor in the cerebral venous blood of rabbits kept asleep by electrical stimulation of the thalamus. When transferred to other animals, it appeared to increase delta-wave (slow-wave) sleep. They purified and sequenced it, and named it delta sleep-inducing peptide.
Almost fifty years later, DSIP is still unusual. No gene or precursor protein that produces it has been confirmed, no dedicated receptor has been identified, and sleep studies have given conflicting results. Researchers have also reported effects on stress hormones, luteinizing-hormone release and body-temperature regulation in animals. That mix of intriguing findings and unresolved basics is exactly why it remains a research compound rather than a medicine.
What DSIP research looks at
- Sleep architecture: slow-wave sleep and EEG changes in animal models.
- Neuroendocrine regulation: effects on corticotropin, luteinizing hormone and somatostatin signalling.
- Stress responses: stress-protective effects reported in rodent models.
- Mechanism hunting: candidate binding partners and the question of an endogenous source.
- Peptide stability: how a short, unprotected peptide survives in biological fluids.
Regulatory status: DSIP is not an authorized drug in Canada, and Health Canada’s April 2026 public advisory on unauthorized injectable peptides names it. We sell it strictly as a laboratory reagent for in-vitro research.
Why researchers order DSIP from Pure Peptides Canada
Choose 5 or 10 mg above. Orders over $299 ship free across Canada.
See lab resultsDSIP FAQ
Where can I buy DSIP in Canada?
Pure Peptides Canada stocks DSIP as a lyophilized research reagent in 5 and 10 mg vials and ships it from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
What does DSIP stand for?
Delta sleep-inducing peptide, named for its reported effect on delta-wave (slow-wave) sleep in the original 1977 rabbit experiments. Its international non-proprietary name is emideltide.
Does DSIP have a known receptor?
No dedicated receptor has been confirmed, and no gene or precursor that produces DSIP has been definitively identified. That gap is a major focus of ongoing research.
Is this DSIP third-party tested?
Yes. The listing links an HPLC purity and mass-spectrometry identity report from Janoshik Analytical, an independent lab. Our COA guide explains how to read it.
Is DSIP approved in Canada?
No. DSIP is not an authorized drug in Canada or elsewhere. It is sold here only as a laboratory reagent for in-vitro research.
Can DSIP be used in people or animals?
No. It is for in-vitro laboratory research only and is not a drug, supplement or food. We do not provide dosing or administration information.
For laboratory research use only. Not a drug, supplement, food or cosmetic, not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Dean Pelletier –
Effective. Sleeping like a normal person now. I love it!
Dennis Cote –
Lowered my chronic pain and allows me to sleep.. I would pay alot more to have those 2 things. Thanks so much
Only side effect I felt was a bit of nausea, but no big deal.