Teriparatide

Description

Teriparatide is a synthetic peptide corresponding to the first 34 amino acids of human parathyroid hormone — PTH(1-34), the receptor-binding portion of the intact hormone. This listing is a research-grade preparation for laboratories in Canada studying PTH1 receptor signalling, bone cell biology and calcium homeostasis in vitro. It is a reagent, not a therapeutic product, and is sold strictly for laboratory research use.

Overview

Each vial contains 750mcg of teriparatide as a lyophilized powder, sealed for reconstitution in a solvent appropriate to the assay. The dry format is what makes a peptide of this class practical to ship and store: in the lyophilized state the material is far less vulnerable to hydrolysis and aggregation than it would be in solution, so the vial can travel and sit in cold storage until the day of use. Vials are offered singly or in a box of ten for laboratories running repeat work or multiple arms of a study, and every lot ships with documentation traceable to that specific batch.

What it is known for

Teriparatide is best known as the biologically active N-terminal fragment of parathyroid hormone, and it is the standard reference molecule for anyone probing PTH1 receptor activation, cAMP signalling in osteoblasts, or the anabolic side of bone remodelling in cell and tissue models. Buyers choose this particular supply for the analytics: independent third-party testing by Janoshik covering purity by HPLC and identity by mass spectrometry, with the certificate matched to the lot in hand rather than a generic reference document. Combined with domestic Canadian dispatch, that means a researcher can verify what arrived and avoid the customs delays and temperature exposure that come with long international transit.

Key features

• PTH(1-34) sequence identity confirmed by mass spectrometry — Confirms the vial contains the intended 34-residue fragment and not a truncated, modified or substituted peptide — the difference between an interpretable result and an unexplained one.
• Purity assessed by HPLC — Quantifies the main peak against process-related impurities, so you know how much of the mass you weigh out is actually the target peptide when calculating working concentrations.
• Independent third-party testing (Janoshik) — The analysis comes from an outside laboratory rather than the seller’s own bench, removing the conflict of interest that makes in-house numbers hard to rely on.
• Batch-matched certificate of analysis — The paperwork corresponds to the lot number on your vial, which is what a supervisor, grant auditor or methods section actually needs.
• 750mcg lyophilized fill — A microgram-scale peptide supplied dry can be reconstituted to the concentration your protocol calls for, and the powder form gives the vial a realistic working life under cold storage.
• Single vial or box of ten — Take one vial to establish conditions, then scale to a case for longitudinal or multi-replicate work without changing lots mid-study.
• Sealed vial, cold-stored and shipped from within Canada — Domestic dispatch keeps transit short and tracked, reducing the time the material spends outside controlled conditions before it reaches your bench.

Benefits

• You can reconcile your own results against documented purity and identity for the exact lot you used
• Fewer confounding variables from unverified material, so anomalous data points are easier to attribute to the experiment rather than the reagent
• Domestic shipping avoids cross-border holds and the temperature excursions that come with them
• Lyophilized supply lets you set your own reconstitution buffer and concentration rather than working around a fixed formulation
• Ordering by the box keeps a single lot in play across a series of experiments, which removes batch-to-batch variation as a source of noise

Specifications

Typical applications

• In-vitro investigation of PTH1 receptor binding and downstream signalling
• Osteoblast and bone-derived cell culture studies
• Calcium and phosphate handling research in cell or tissue models
• Reference or comparator peptide in analytical method development
• Assay development and validation work requiring a characterized peptide standard

Important information

• Research use only. This product is not a drug, supplement, food or cosmetic, is not intended to diagnose, treat, cure or prevent any disease, and is not for human or veterinary use, ingestion or administration.
• Keep the vial cold and sealed until use; peptides of this class are markedly less stable once in solution than in the lyophilized state.
• Reconstitute in a solvent suited to your assay and handle the vial with sterile technique — teriparatide is supplied without preservative.
• Allow the vial to reach a workable temperature before opening to limit condensation on the cake.
• Review the certificate of analysis for your lot before setting working concentrations, and record the lot number in your methods.
• Confirm the peptide is compatible with the buffers, plasticware and detection chemistry in your protocol before committing material.

Common questions

What exactly is teriparatide?

It is a synthetic peptide made up of the first 34 amino acids of human parathyroid hormone, the N-terminal region responsible for engaging the PTH1 receptor. Researchers use it as a defined, single-molecule stand-in for the intact hormone in receptor and bone biology work.

Can I see the certificate of analysis for the lot I receive?

Yes. Every batch is tested independently by Janoshik for purity by HPLC and identity by mass spectrometry, and the certificate is matched to the batch you are sent rather than being a generic sample document.

How should the vial be stored?

Cold, sealed and dry until the point of reconstitution. Lyophilized peptide is considerably more stable than peptide in solution, so leave it in powder form until you are ready to use it, and follow your own laboratory’s handling standards for reconstituted material.

What does 750mcg mean in practice?

That is the mass of peptide in the vial before reconstitution. Because it is supplied dry, you choose the solvent volume and therefore the working concentration — the certificate of analysis purity figure is what you should factor into that calculation.

Why order the box of ten rather than single vials?

A case keeps a single lot available across an extended set of experiments, so batch variation is not competing with the variable you are actually testing. It also means fewer separate shipments for laboratories running repeat protocols.

Is this suitable for human use?

No. It is a laboratory reagent sold for in-vitro research only, and is not intended for human or veterinary administration in any form.

In summary

A characterized PTH(1-34) reagent supplied dry in 750mcg vials, with independent HPLC and mass spectrometry data tied to the lot you receive and domestic Canadian dispatch behind it. If your work depends on knowing what is in the vial, the documentation is the point.