Description
Prostamax is the synthetic tetrapeptide Lys-Glu-Asp-Pro (KEDP), a St. Petersburg bioregulator that its developers assign to the prostate, although the main published experiment on it examined chromatin in white blood cells from people aged 75 to 88. Pure Peptides Canada supplies it as a lyophilized research reagent in 20 mg vials, with an independent Janoshik HPLC and mass-spectrometry report, CAD pricing and tracked shipping from inside Canada.
Prostamax at a glance
- What it is: L-lysyl-L-glutamyl-L-aspartyl-L-proline (KEDP), a synthetic tetrapeptide from Vladimir Khavinson’s bioregulator programme.
- What researchers study: chromatin condensation and ribosomal-gene activity in blood cells from elderly donors, predicted DNA binding, and structure–activity comparisons across the KED tetrapeptides.
- Evidence level: chromatin work in blood cells from elderly donors plus DNA modelling and chemistry, from the developers and their collaborators; we could not verify any animal study, and we found no peer-reviewed controlled trial in people.
- Supplied as: sealed lyophilized powder, 20 mg, single vial or box of 10.
- Delivery: ships from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
Prostamax
Lys-Glu-Asp-Pro · KEDP tetrapeptide · prostate-associated bioregulator
- K
- E
- D
- P
Lysine, glutamic acid, aspartic acid, proline.
- Length
- 4 amino acids
- Molecular formula
- C20H33N5O9
- Molecular weight
- ≈ 487.5 g/mol
- Family
- Khavinson short-peptide bioregulators
- Form
- Lyophilized powder, sealed vial
- Sizes
- 20 mg (single or box of 10)
- SKU
- PP-PROSTAMAX
Where the evidence stands
- Cell studies
- Animal models
- Controlled human trials
- Approved medicine
Published work is mainly cell and tissue-culture research from the developers’ network. Prostamax is not an approved medicine.
What is Prostamax?
Prostamax is one of four tetrapeptides in the catalogue that start with Lys-Glu-Asp (KED) and differ only in the fourth residue: Livagen (KEDA), Testagen (KEDG), Pancragen (KEDW) and Prostamax (KEDP). Vesugen is the KED tripeptide on its own. The C-terminal proline is what distinguishes Prostamax, and it creates a second family link: its last three residues, Glu-Asp-Pro, are the tripeptide Crystagen, and Cortagen (Ala-Glu-Asp-Pro) ends the same way.
In the developers’ physicochemical comparison of their peptides, Prostamax is listed at about 0.49 kDa with a net charge of −1 and a strongly negative hydrophobicity index, which marks it as a highly hydrophilic, charged molecule (Khavinson et al., Biology Bulletin Reviews, 2013). The developers link it to the prostate, but the experiments that can be traced in the literature concern chromatin and DNA rather than prostate tissue, and we could not verify any peer-reviewed study of the synthetic peptide in prostate cells or animals.
What published studies report
We could verify one experimental study, plus modelling and review statements, all from the developers’ network.
- Chromatin in cells from people aged 75–88 (2004): in leukocytes from elderly donors, the group compared five bioregulators: Vilon, Epithalon, Livagen, Prostamax and Cortagen. All five were reported to activate ribosomal genes and to loosen densely packed facultative heterochromatin; Prostamax, Epithalon and Livagen also decondensed the pericentromeric structural heterochromatin of chromosome 1, and only Epithalon and Livagen changed chromosome 9 (Khavinson et al., Bulletin of Experimental Biology and Medicine, 2004). The read-outs were cytogenetic staining and chromatin melting rather than gene-expression profiling or cell function, and no prostate tissue was involved.
- Predicted DNA binding (2016): in the group’s computer docking of short peptides against DNA, KEDP was predicted to bind the sequence ATTC strongly (Khavinson et al., Bulletin of Experimental Biology and Medicine, 2016). A modelling result without experimental confirmation in that paper.
- DNA stability (2021 review): the group’s systematic review lists KEDP, with Vilon (KE) and Epithalon (AEDG), among short peptides reported to change the melting temperature and stability of double-stranded DNA (Khavinson et al., Molecules, 2021). A summary statement about purified DNA; it says nothing about cells.
What is not established
Whether Prostamax does anything specific in prostate cells or tissue; whether the chromatin changes seen in blood cells from elderly donors alter gene expression or cell behaviour; and whether the results hold outside the network that produced them. The prostate assignment comes from the developers, and we could not verify a published experiment that tests it.
Regulatory status: Prostamax is not an authorized drug in Canada. We sell it strictly as a laboratory reagent for in-vitro research.
Why researchers order Prostamax from Pure Peptides Canada
Add a 20 mg vial or a box of 10 above. Orders over $299 ship free across Canada.
See lab resultsProstamax FAQ
Where can I buy Prostamax in Canada?
Pure Peptides Canada stocks Prostamax as a lyophilized research reagent in 20 mg vials and ships it from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
What is the difference between Prostamax and Testagen?
Both are KED tetrapeptides. Prostamax ends in proline (KEDP, about 487.5 g/mol) and Testagen in glycine (KEDG, about 447.4 g/mol). Their developers link them to the prostate and the testis respectively.
What does the published research on Prostamax cover?
Mainly blood cells from donors aged 75 to 88, in which it loosened condensed chromatin, plus computer modelling and test-tube work on DNA binding. We could not verify any peer-reviewed study in prostate tissue or animals, and found no peer-reviewed controlled trial in people.
How is Prostamax related to Crystagen and Cortagen?
All three end in Glu-Asp-Pro. Crystagen is that tripeptide on its own, Cortagen adds an N-terminal alanine (Ala-Glu-Asp-Pro) and Prostamax an N-terminal lysine (Lys-Glu-Asp-Pro).
Can Prostamax be used in people or animals?
No. This product is for in-vitro laboratory research only and is not a drug, supplement or food. We do not provide dosing or administration information.
References
- Khavinson VK, Lezhava TA, Malinin VV. Effects of short peptides on lymphocyte chromatin in senile subjects. Bull Exp Biol Med. 2004;137(1):78–81. DOI
- Khavinson VKh, Lin’kova NS, Tarnovskaya SI. Short peptides regulate gene expression. Bull Exp Biol Med. 2016;162(2):288–292. DOI
- Khavinson VKh, Solov’ev AYu, Tarnovskaya SI, Lin’kova NS. Mechanism of biological activity of short peptides: cell penetration and epigenetic regulation of gene expression. Biol Bull Rev. 2013;3(6):451–455. DOI
- Khavinson VK, Popovich IG, Linkova NS, Mironova ES, Ilina AR. Peptide regulation of gene expression: a systematic review. Molecules. 2021;26(22):7053. DOI
For laboratory research use only. Not a drug, supplement, food or cosmetic, not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
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