Description
GHRP-6 is the original growth-hormone-releasing hexapeptide, described by Cyril Bowers in 1984, fifteen years before ghrelin itself was discovered. It remains the classic reference compound for ghrelin-receptor research. Pure Peptides Canada supplies it as a lyophilized research reagent in 10 mg vials, with an independent Janoshik HPLC and mass-spectrometry report, CAD pricing and tracked shipping from inside Canada.
GHRP-6 at a glance
- What it is: His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, a six-residue ghrelin-receptor (GHS-R1a) agonist and the first synthetic peptide of its class.
- What researchers study: GHS-R1a signalling, appetite and feeding behaviour, and cytoprotection in heart and gut models.
- Evidence level: extensive cell and animal work plus human pharmacology studies. Never approved as a medicine.
- Supplied as: sealed lyophilized powder, 10 mg, single vial or box of 10.
- Delivery: ships from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
GHRP-6
Growth-hormone-releasing peptide 6 · SKF-110679 · hexapeptide
- His
- D-Trp
- Ala
- Trp
- D-Phe
- Lys
- NH₂
Blue: D-amino acids that resist enzymatic breakdown. Outlined: C-terminal amide.
- Length
- 6 amino acids, C-terminal amide
- Molecular formula
- C46H56N12O6
- Molecular weight
- ≈ 873 g/mol
- CAS number
- 87616-84-0
- Target
- Ghrelin receptor (GHS-R1a)
- Form
- Lyophilized powder, sealed vial
- Sizes
- 10 mg (single or box of 10)
- SKU
- PP-GHRP6
Where the evidence stands
- Cell studies
- Animal models
- Human studies
- Approved medicine
Human data comes from pharmacology studies. GHRP-6 is not an approved medicine anywhere.
What is GHRP-6?
In the late 1970s and early 1980s, Cyril Bowers at Tulane University began modifying small opioid-like peptides and found that some released growth hormone through a receptor that was not the GHRH receptor. GHRP-6, reported in 1984, was the standout. For years its receptor was an orphan. When ghrelin was discovered in 1999, it turned out GHRP-6 had been mimicking it all along by activating GHS-R1a.
GHRP-6 behaves much like ghrelin in study models, including a strong stimulation of appetite that later GHRPs show less. Research has also looked at cytoprotective effects in heart, liver and gut injury models, a line of work that continues independently of growth hormone. Its long publication record makes it the default comparator for newer ghrelin-receptor agonists.
What GHRP-6 research looks at
- Ghrelin-receptor pharmacology: GHS-R1a activation and downstream signalling.
- Appetite and feeding: ghrelin-like effects on food intake in animal models.
- Cytoprotection: heart, liver and gastrointestinal injury models.
- GHRP family comparisons: potency and selectivity against GHRP-2, hexarelin and ipamorelin.
- GHRH synergy: combined studies with GHRH analogues such as sermorelin.
Regulatory status: GHRP-6 is not an authorized drug in Canada, and growth-hormone secretagogues are on the World Anti-Doping Agency prohibited list. We sell it strictly as a laboratory reagent for in-vitro research.
Why researchers order GHRP-6 from Pure Peptides Canada
Add a 10 mg vial or a box of 10 above. Orders over $299 ship free across Canada.
See lab resultsGHRP-6 FAQ
Where can I buy GHRP-6 in Canada?
Pure Peptides Canada stocks GHRP-6 as a lyophilized research reagent in 10 mg vials and ships it from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
What is the difference between GHRP-6 and GHRP-2?
GHRP-6 is the original 1984 peptide. GHRP-2 is a more potent second-generation analogue. GHRP-6 is known for a stronger appetite effect in study models. See our GHRP-6 vs GHRP-2 vs hexarelin comparison.
How is GHRP-6 related to ghrelin?
GHRP-6 activates the same receptor as ghrelin, GHS-R1a. It was discovered first, and its unknown receptor was one of the leads that eventually led to ghrelin’s discovery in 1999.
Is this GHRP-6 third-party tested?
Yes. The listing links an HPLC purity and mass-spectrometry identity report from Janoshik Analytical, an independent lab. Our COA guide explains how to read it.
Is GHRP-6 approved in Canada?
No. GHRP-6 is not an authorized drug in Canada or elsewhere. It is sold here only as a laboratory reagent for in-vitro research.
Can GHRP-6 be used in people or animals?
No. This product is for in-vitro laboratory research only and is not a drug, supplement or food. We do not provide dosing or administration information.
For laboratory research use only. Not a drug, supplement, food or cosmetic, not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
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