Description
GHRP-2, also called pralmorelin, is a synthetic hexapeptide from Cyril Bowers’ pioneering growth-hormone-releasing peptide programme. It is one of the most potent ghrelin-receptor agonists in the GHRP family. Pure Peptides Canada supplies it as a lyophilized research reagent in 10 mg vials, with an independent Janoshik HPLC and mass-spectrometry report, CAD pricing and tracked shipping from inside Canada.
GHRP-2 at a glance
- What it is: D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NH2, a six-residue ghrelin-receptor (GHS-R1a) agonist built from D-amino acids for stability.
- What researchers study: GHS-R1a pharmacology, potency comparisons across the GHRP family, and synergy with GHRH analogues.
- Evidence level: cell, animal and human pharmacology studies. In Japan it was approved as a diagnostic agent for growth-hormone deficiency testing.
- Supplied as: sealed lyophilized powder, 10 mg, single vial or box of 10.
- Delivery: ships from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
GHRP-2
Pralmorelin · KP-102 · growth-hormone-releasing peptide 2
- D-Ala
- D-2Nal
- Ala
- Trp
- D-Phe
- Lys
- NH₂
Blue: D-amino acids and non-natural residues that resist enzymatic breakdown. Outlined: C-terminal amide.
- Length
- 6 amino acids, C-terminal amide
- Molecular formula
- C45H55N9O6
- Molecular weight
- ≈ 818 g/mol
- CAS number
- 158861-67-7
- Target
- Ghrelin receptor (GHS-R1a)
- Form
- Lyophilized powder, sealed vial
- Sizes
- 10 mg (single or box of 10)
- SKU
- PP-GHRP2
Where the evidence stands
- Cell studies
- Animal models
- Human studies
- Approved in Canada
Approved in Japan only, as a diagnostic agent. GHRP-2 is not authorized in Canada.
What is GHRP-2?
Before ghrelin was discovered in 1999, Cyril Bowers and colleagues at Tulane University were designing small synthetic peptides that released growth hormone through an unknown receptor. GHRP-6 came first. GHRP-2 followed as a more potent second-generation version, with D-alanine and D-2-naphthylalanine at the front to strengthen receptor binding and resist peptidases. When the receptor was later identified as GHS-R1a, the ghrelin receptor, these peptides became key tools for studying it.
In human pharmacology studies GHRP-2 produced strong growth-hormone release, with smaller rises in cortisol and prolactin than some researchers expected. It was later developed in Japan as pralmorelin, a diagnostic agent for growth-hormone deficiency testing. In combination with GHRH analogues it shows the synergy that underpins most two-pathway secretagogue research.
What GHRP-2 research looks at
- Ghrelin-receptor pharmacology: binding, potency and signalling at GHS-R1a.
- GHRP family comparisons: potency and selectivity against GHRP-6, hexarelin and ipamorelin.
- Stress-axis effects: cortisol, ACTH and prolactin responses alongside growth hormone.
- GHRH synergy: combined studies with CJC-1295 No DAC or sermorelin.
- Appetite signalling: ghrelin-like effects on food intake in animal models.
Regulatory status: GHRP-2 is not an authorized drug in Canada, and growth-hormone secretagogues are on the World Anti-Doping Agency prohibited list. We sell it strictly as a laboratory reagent for in-vitro research.
Why researchers order GHRP-2 from Pure Peptides Canada
Add a 10 mg vial or a box of 10 above. Orders over $299 ship free across Canada.
See lab resultsChecking a GHRP-2 identity report
Compare these values with the mass-spectrometry result for a GHRP-2 peptide batch. They are calculated from the sequence D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NH2 (C45H55N9O6), where 2Nal is 3-(2-naphthyl)alanine:
- Monoisotopic mass: 817.43 Da (average molecular weight about 818.0 g/mol).
- Expected ions: [M+H]+ at m/z 818.43 and [M+2H]2+ at m/z 409.72.
- Stereochemistry: the three D-residues weigh the same as their L-forms, so mass spectrometry cannot confirm configuration. Chiral HPLC or comparison with a reference standard can.
- Mix-up check: GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, C46H56N12O6) appears at [M+H]+ m/z 873.45, so a main peak there points to GHRP-6 rather than GHRP-2.
For peaks beyond the main ion, such as isotopes and adducts, see how to read a peptide mass spectrum. The Lab Testing page sets out what HPLC purity and mass-spectrometry identity results can and cannot tell you.
GHRP-2 FAQ
Where can I buy GHRP-2 in Canada?
Pure Peptides Canada stocks GHRP-2 as a lyophilized research reagent in 10 mg vials and ships it from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
What is the difference between GHRP-2 and GHRP-6?
Both activate the ghrelin receptor. GHRP-2 is the more potent second-generation peptide. GHRP-6 is the original, known in animal and human studies for a stronger appetite effect. Our GHRP-6 vs GHRP-2 vs hexarelin comparison covers the details.
How does GHRP-2 compare with ipamorelin?
Ipamorelin is more selective: in its original animal studies it released growth hormone without raising cortisol or ACTH. GHRP-2 is more potent but less selective.
Is this GHRP-2 third-party tested?
Yes. The listing links an HPLC purity and mass-spectrometry identity report from Janoshik Analytical, an independent lab. Our COA guide explains how to read it.
Is GHRP-2 approved in Canada?
No. Pralmorelin was approved in Japan as a diagnostic agent, but GHRP-2 is not an authorized drug in Canada. It is sold here only as a laboratory reagent for in-vitro research.
Can GHRP-2 be used in people or animals?
No. This product is for in-vitro laboratory research only and is not a drug, supplement or food. We do not provide dosing or administration information.
For laboratory research use only. Not a drug, supplement, food or cosmetic, not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Camila –
Great Peptide. Simple order process. No complaints