Description
ARA-290 (cibinetide) is an 11-residue peptide modelled on helix B of erythropoietin. It activates EPO’s tissue-protective “innate repair receptor” without stimulating red blood cell production. It has been taken into Phase 2 trials for small-fibre neuropathy. Pure Peptides Canada supplies it as a lyophilized research reagent in 16 mg vials, with an independent Janoshik HPLC and mass-spectrometry report, CAD pricing and tracked shipping from inside Canada.
ARA-290 at a glance
- What it is: pGlu-EQLERALNSS, a synthetic peptide based on the helix B surface of erythropoietin.
- Why it matters: it separates EPO’s tissue-protective signalling from its blood-forming effect, which full-length EPO cannot do.
- Evidence level: cell and animal work plus small Phase 2 human trials in sarcoidosis-associated and diabetic neuropathy. Not approved.
- Supplied as: sealed lyophilized powder, 16 mg, single vial or box of 10.
- Delivery: ships from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
ARA-290
Cibinetide · helix B surface peptide · innate repair receptor agonist
- pGlu
- E
- Q
- L
- E
- R
- A
- L
- N
- S
- S
Blue: N-terminal pyroglutamate. Sequence based on helix B of erythropoietin.
- Length
- 11 amino acids
- Molecular formula
- C51H84N16O21
- Molecular weight
- ≈ 1257 g/mol
- CAS number
- 1208243-50-8
- Target
- Innate repair receptor (EPOR / CD131 heteromer)
- Form
- Lyophilized powder, sealed vial
- Sizes
- 16 mg (single or box of 10)
- SKU
- PP-ARA290CIBINETIDE
Where the evidence stands
- Cell studies
- Animal models
- Controlled human trials
- Approved medicine
Small Phase 2 trials reported improvements in neuropathy measures. ARA-290 is not an approved medicine.
What is ARA-290?
Erythropoietin does two things. It drives red blood cell production through the classic EPO receptor, and in damaged tissues it protects cells through a different receptor complex, EPOR paired with the beta-common receptor CD131, which researchers call the innate repair receptor. Using full-length EPO to study tissue protection is complicated because it also raises red cell counts. Michael Brines and Anthony Cerami found that the tissue-protective activity maps to one face of the molecule, helix B, and designed a short peptide from it: ARA-290.
In animal models ARA-290 reduced inflammation and nerve damage without any blood-forming effect. Araim Pharmaceuticals took it into Phase 2 trials, where small studies in sarcoidosis-associated small-fibre neuropathy and diabetic neuropathy reported improvements in nerve-fibre density and symptom scores. Those trials were small, and cibinetide has not been approved.
What ARA-290 research looks at
- Innate repair receptor signalling: EPOR/CD131 activation without erythropoiesis.
- Neuropathy models: small-fibre nerve regeneration and neuropathic pain.
- Inflammation: cytokine responses in tissue-injury models.
- Metabolic models: insulin sensitivity and islet protection in rodents.
- EPO structure-function: how one face of a hormone carries a separable activity.
Regulatory status: ARA-290 is not an authorized drug in Canada. We sell it strictly as a laboratory reagent for in-vitro research.
Why researchers order ARA-290 from Pure Peptides Canada
Add a 16 mg vial or a box of 10 above. Orders over $299 ship free across Canada.
See lab resultsARA-290 FAQ
Where can I buy ARA-290 in Canada?
Pure Peptides Canada stocks ARA-290 (cibinetide) as a lyophilized research reagent in 16 mg vials and ships it from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
Is ARA-290 the same as EPO?
No. Erythropoietin is a 165-residue glycoprotein hormone. ARA-290 is an 11-residue peptide based on one surface of it, and it does not stimulate red blood cell production.
What is the innate repair receptor?
A receptor complex of the EPO receptor and CD131 (the beta-common receptor) that appears in stressed or injured tissue and mediates EPO’s protective effects. ARA-290 was designed to activate it selectively. Our ARA-290 guide explains the biology.
Is this ARA-290 third-party tested?
Yes. An HPLC purity and mass-spectrometry identity report from Janoshik Analytical, an independent lab, is listed on our Lab Testing page. Our COA guide explains how to read it.
Can ARA-290 be used in people or animals?
No. This product is for in-vitro laboratory research only and is not a drug, supplement or food. We do not provide dosing or administration information.
For laboratory research use only. Not a drug, supplement, food or cosmetic, not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Further reading: What the FDA’s 2026 peptide reviews say about seven research compounds.
Steve C. –
ARA-290 works great for me. Super happy to have found this product. Fast delivery, great customer service and good prices on products.