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Articles on SLU-PP-332, the estrogen-related receptor agonist studied in mouse exercise-biology research, and what has not yet been tested.
How adult human brown fat was confirmed in 2009, what UCP1 actually does, why FDG-PET does not measure heat production, how little energy brown fat is measured to burn, and why none of the compounds sold as thermogenic acts on it.
What AMP-activated protein kinase is, how LKB1 and CaMKK2 switch it on, what it turns on and off, why metformin's AMPK link is still contested, and which research compounds genuinely act on it.
SLU-PP-332 explained: the estrogen-related receptor agonist behind the exercise-in-a-pill headlines, what the mouse studies found, and what has never been tested.