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Articles on sermorelin, the 29-amino-acid GHRH fragment, its research history and how it compares with newer GHRH analogues.
How a peptide signal outside a cell becomes a response inside it: adenylyl cyclase, cyclic AMP, protein kinase A and CREB, why GHRH analogues and growth hormone secretagogues use different routes, and what the cascade diagram leaves out.
The inhibitory half of the growth hormone axis: what somatostatin is, the five receptors it works through, why its three-minute half-life produced octreotide, and why the claim that GHRPs suppress it is not supported.
Sermorelin and ipamorelin compared: a 29-residue fragment of a human hormone against a designed pentapeptide, their very different regulatory histories, and why no study has tested one against the other.
Sermorelin explained: the 29-amino-acid GHRH fragment, its FDA history as Geref, how it compares with tesamorelin and CJC-1295, and sourcing in Canada.