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Articles on FOXO4-DRI, the senolytic peptide studied in mouse ageing research, and on sourcing it in Canada for laboratory use.
The seven mammalian sirtuins, why NAD+ is consumed rather than used as a cofactor, the replication failure that reset the lifespan claims, the resveratrol assay artefact, and what the SIRT1-FOXO4 link does and does not imply.
What senescent 'zombie' cells are, how senolytics such as dasatinib plus quercetin, fisetin, navitoclax and FOXO4-DRI were discovered, and what the first human trials have and haven't shown.
What cell-penetrating peptides are, how the Tat and penetratin discoveries happened, why the 2003 fixation artefact reset the field, why endosomal escape is still the bottleneck, and where CPPs stand today.
FOXO4-DRI explained: the 2017 Erasmus MC senolytic peptide that frees p53 to clear senescent cells, what the mouse studies showed, and Canadian sourcing.