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Research guides to peptides studied in ageing biology, such as GHK-Cu, Epitalon, MOTS-c and FOXO4-DRI: what the studies found and what remains unproven.
The seven mammalian sirtuins, why NAD+ is consumed rather than used as a cofactor, the replication failure that reset the lifespan claims, the resveratrol assay artefact, and what the SIRT1-FOXO4 link does and does not imply.
What senescent 'zombie' cells are, how senolytics such as dasatinib plus quercetin, fisetin, navitoclax and FOXO4-DRI were discovered, and what the first human trials have and haven't shown.
NAD+ explained: why this coenzyme matters, how NMN and nicotinamide riboside feed it, what human trials of the precursors found, and what remains unproven.
Telomeres and telomerase explained: how chromosome caps shorten, the enzyme that rebuilds them, why longer isn't always better, and Epitalon's claims.
MOTS-c explained: the 16-amino-acid peptide encoded in mitochondrial DNA, its AMPK and exercise research, what human data exist, and sourcing in Canada.
Argireline and SNAP-8 explained: the SNAP-25-mimicking cosmetic peptides, what the 2002 and 2013 studies found, the evidence gaps, and sourcing in Canada.
Anti-aging peptides explained: GHK-Cu, Epitalon, MOTS-c, SS-31, FOXO4-DRI and more, mapped to the hallmarks of ageing they target, plus sourcing in Canada.
FOXO4-DRI explained: the 2017 Erasmus MC senolytic peptide that frees p53 to clear senescent cells, what the mouse studies showed, and Canadian sourcing.
Epitalon (Epithalon) explained: the AEDG tetrapeptide, the telomerase studies, what has and hasn't been replicated, and sourcing it in Canada.
MOTS-c, SS-31 (elamipretide) and humanin compared: where each comes from, what the research shows, the 2025 FDA approval, and sourcing in Canada.