Description
PTD-DBM is an experimental peptide that joins a cell-penetrating protein transduction domain (PTD) to the Dishevelled-binding motif (DBM) of the protein CXXC5. Developed at Yonsei University in Seoul, it is used to block CXXC5’s brake on Wnt/β-catenin signalling in hair-follicle and wound-healing research. Pure Peptides Canada supplies it only as a lyophilized laboratory reagent in 5 mg vials. It is not a hair-loss treatment and is not for human use.
PTD-DBM at a glance
- What it is: a competitor peptide that mimics the part of CXXC5 that binds Dishevelled, carried into cells by a protein transduction domain.
- What researchers study: negative-feedback control of Wnt/β-catenin signalling, hair-follicle regeneration and wound-induced hair neogenesis in mice.
- Evidence level: cell and mouse studies, mainly from the group that developed it. No human trials. Not approved anywhere.
- Supplied as: sealed lyophilized powder, 5 mg, single vial or box of 10.
- Delivery: ships from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299.
Regulatory status: PTD-DBM is an experimental compound and has not been approved anywhere. It is not a cosmetic or a hair-loss treatment. We sell it strictly as a laboratory reagent for in-vitro research to qualified research buyers, and we do not provide dosing, administration or medical information.
PTD-DBM
Protein transduction domain–Dishevelled-binding motif · CXXC5–Dvl competitor peptide
- Design
- Cell-penetrating protein transduction domain linked to the Dishevelled-binding motif of CXXC5
- Pathway studied
- Wnt/β-catenin, via the CXXC5–Dishevelled interaction
- Origin
- Kang-Yell Choi laboratory, Yonsei University, Seoul
- Key paper
- Journal of Investigative Dermatology, 2017
- Form
- Lyophilized powder, sealed vial
- Sizes
- 5 mg (single or box of 10)
- SKU
- PP-PTDPLUSDBM
Where the evidence stands
- Cell studies
- Animal models
- Controlled human trials
- Approved medicine
Published work is mainly from the developers’ group, in cell culture and mice. PTD-DBM is not an approved medicine or cosmetic ingredient.
What is PTD-DBM?
Wnt/β-catenin signalling drives hair-follicle development and regeneration. The protein CXXC5 acts as a brake on that pathway: it binds Dishevelled (Dvl), a key relay protein, and dampens the signal. Kang-Yell Choi’s group at Yonsei University designed PTD-DBM to compete with CXXC5 for Dishevelled. The DBM portion mimics CXXC5’s Dishevelled-binding region, and the PTD carries the peptide across cell membranes.
In a 2017 study in the Journal of Investigative Dermatology, titled “Targeting of CXXC5 by a competing peptide stimulates hair re-growth and wound-induced hair neogenesis”, the group reported that topically applied PTD-DBM promoted hair regrowth in mice, and that combining it with valproic acid, a Wnt-pathway activator, enhanced wound-induced hair neogenesis. These are mouse results from one research group; no human trials have been reported.
What PTD-DBM research looks at
- Wnt/β-catenin regulation: CXXC5 as a negative-feedback regulator and how competitor peptides relieve it.
- Hair-follicle biology: follicle cycling and regeneration in mouse models.
- Wound-induced hair neogenesis: new follicle formation in healing skin.
- Cell-penetrating peptides: protein transduction domains as carriers for intracellular targets.
Ordering PTD-DBM for laboratory research
Ask us for the full sequence and expected mass for your lot before you order.
See lab resultsPTD-DBM FAQ
Where can I buy PTD-DBM in Canada?
Pure Peptides Canada supplies PTD-DBM only as a lyophilized laboratory reagent in 5 mg vials, shipped from inside Canada by tracked Xpresspost in 3–7 days ($25 CAD), or free in 4–12 days on orders over $299. It is not sold for human use.
Is PTD-DBM a hair-loss treatment?
No. PTD-DBM has been studied in cell culture and mice only and has not been approved as a medicine or cosmetic ingredient anywhere. We supply it strictly for in-vitro research.
How does PTD-DBM work in research models?
It competes with CXXC5 for binding to Dishevelled. Because CXXC5 normally dampens Wnt/β-catenin signalling, blocking it lets the pathway run more strongly, which in mice was linked to hair-follicle regeneration.
How do I confirm the identity of a PTD-DBM batch?
Ask us for the full sequence and expected mass for your lot, then check that the mass-spectrometry result matches it. Our COA guide explains what else to look for.
Can PTD-DBM be used in people or animals?
No. This product is for in-vitro laboratory research only and is not a drug, supplement, food or cosmetic. We do not provide dosing or administration information.
For laboratory research use only. Not a drug, supplement, food or cosmetic, not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
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